Sperm & semen · In plain English

Sperm DNA fragmentation

Damage or breaks in sperm genetic material assessed using specialised tests. It is different from the appearance of sperm under a microscope.

Also searched as: DNA fragmentation index, DFI, SDF

Why you might see this term

Different methods can give different results. A clinician should explain why testing is being considered and whether it could change a decision.

What to keep in mind

There is no single universally agreed threshold across methods, and evidence for treatments offered after a high result is uncertain. It is not a routine requirement for everyone.

Sources & further reading

Prepared by ProFertility · Updated 23 October 2026.

Educational information based on the linked sources. This explanation is not an individual diagnosis or a treatment recommendation. A term appearing here does not mean the test is necessary or included in a particular kit.

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